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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

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Published on: December 3, 2020

Liver abnormalities in pregnancy.

Nwe Ni Than1, James Neuberger

  • 1Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

Liver function changes are common in pregnancy. Specific elevations in bilirubin and aminotransferase may indicate serious liver disease, necessitating prompt diagnosis for better maternal and fetal outcomes.

Keywords:
Acute fatty liverCholestasis of pregnancyHELLP syndromeLiver diseasePre-eclampsiaPregnancy

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Published on: February 10, 2015

Area of Science:

  • Hepatology
  • Obstetrics
  • Maternal-Fetal Medicine

Background:

  • Pregnancy commonly causes liver function abnormalities like elevated alkaline phosphatase and decreased albumin.
  • Elevated bilirubin and aminotransferase levels in pregnant women can signal underlying liver disease, pregnancy-related liver conditions, or unrelated liver issues.
  • Hepatitis E virus infection is associated with poorer outcomes in pregnant women.

Purpose of the Study:

  • To review common and serious liver diseases encountered during pregnancy.
  • To highlight the importance of timely diagnosis and management for maternal and fetal well-being.
  • To outline current treatment strategies for specific pregnancy-related liver conditions.

Main Methods:

  • Literature review of liver diseases in pregnancy.
  • Analysis of diagnostic indicators for liver dysfunction in pregnant patients.
  • Summary of established and emerging treatment protocols.

Main Results:

  • Pregnancy-associated liver diseases include hyperemesis gravidarum, acute fatty liver disease, pre-eclampsia, cholestasis of pregnancy, and HELLP syndrome.
  • Prompt diagnosis is crucial for successful maternal and fetal outcomes.
  • Treatment varies, with delivery often indicated for acute fatty liver, pre-eclampsia, and HELLP syndrome; ursodeoxycholic acid is used for cholestasis.

Conclusions:

  • Recognizing and differentiating liver function abnormalities in pregnancy is vital.
  • Prompt intervention and appropriate management significantly improve maternal and fetal prognoses.
  • Specific conditions require tailored management, including timely delivery or medical therapy.