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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...

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Updated: May 7, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Liver disease and malnutrition.

Tugrul Purnak1, Yusuf Yilmaz

  • 1Department of Gastroenterology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary

Patients with liver disease are at high risk of malnutrition, impacting health outcomes and costs. Early nutrition screening and interventions are crucial for managing this condition and improving patient prognosis.

Keywords:
AnthropometryCirrhosisClinical outcomesLiverNutritionSubjective global assessment

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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Area of Science:

  • Hepatology
  • Clinical Nutrition
  • Gastroenterology

Background:

  • The liver's central role in metabolism makes patients with hepatic disorders highly susceptible to malnutrition.
  • Chronic liver diseases can impair appetite, leading to reduced nutrient intake and poor nutritional status.
  • Malnutrition is prevalent in liver disease patients, especially those with alcoholic cirrhosis, increasing adverse outcomes and healthcare expenses.

Purpose of the Study:

  • To comprehensively analyze methods for identifying malnutrition in chronic liver disease patients.
  • To assess the prevalence and impact of malnutrition in specific patient populations with liver disorders.

Main Methods:

  • Review of existing literature on malnutrition assessment in hepatic disorders.
  • Analysis of nutrition screening tools such as Subjective Global Assessment and anthropometric measurements.
  • Examination of patient data regarding nutritional status and clinical outcomes.

Main Results:

  • Hepatic disorders significantly increase the risk of malnutrition.
  • Malnourished patients with liver disease face higher risks of adverse clinical outcomes and increased healthcare costs.
  • Early identification through nutrition screening is vital for initiating timely interventions.

Conclusions:

  • Implementing robust nutrition policies and protocols is essential for monitoring patients with chronic liver diseases.
  • Evidence-based nutritional interventions are critical to mitigate malnutrition and improve patient prognosis.
  • Proactive nutritional management is key to addressing the challenges posed by malnutrition in liver disease.