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Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach
Michael P Dwyer1, Kartik Keertikar, Kamil Paruch
1Department of Chemical Research, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
Bioorganic & Medicinal Chemistry Letters
|October 5, 2013
Abstract:
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described.

