Related Experiment Video
Updated: May 7, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
Published on: March 14, 2018
Cell division: control of the chromosomal passenger complex in time and space
Armando van der Horst1, Susanne M A Lens
1Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, STR 2.131, 3584, CG, Utrecht, The Netherlands.
Abstract:
The ultimate goal of cell division is equal transmission of the duplicated genome to two new daughter cells. Multiple surveillance systems exist that monitor proper execution of the cell division program and as such ensure stability of our genome. One widely studied protein complex essential for proper chromosome segregation and execution of cytoplasmic division (cytokinesis) is the chromosomal passenger complex (CPC). This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis. Not surprisingly, it also performs various functions during these phases of the cell cycle. In this review, we will give an overview of the latest insights into the regulation of CPC localization and discuss if and how specific localization impacts its diverse functions in the dividing cell.
Related Concept Videos
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
Forces Acting on Chromosomes
Microtubules and motor proteins exert two types of forces on...
Forces Acting on Chromosomes
Microtubules and motor proteins exert two types of forces on...
The Cell Cycle Control System
The Cell Cycle Control System
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

