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Interferon-sensitive coxsackievirus variants in nature.

G W Jordan, V Bolton

    Journal of Interferon Research
    |January 1, 1985
    PubMed
    Summary

    Naturally occurring coxsackie B-4 virus variants with different interferon (IFN) sensitivities were identified. IFN sensitivity impacts coxsackievirus virulence but did not lead to diabetes in mice.

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    Area of Science:

    • Virology
    • Immunology
    • Pathogenesis

    Background:

    • Coxsackie B viruses are known human pathogens.
    • Interferon (IFN) sensitivity is a characteristic of some viruses.
    • Viral variants can exhibit different biological properties.

    Purpose of the Study:

    • To investigate the existence and properties of coxsackievirus B-4 variants with differing interferon (IFN) sensitivity.
    • To determine if IFN sensitivity influences viral virulence.
    • To assess the diabetogenic potential of these variants in a mouse model.

    Main Methods:

    • Selection of coxsackievirus B-4 variants based on IFN sensitivity from clinical isolates and mouse-passaged stocks.
    • Assessment of IFN sensitivity stability through plaque selection.
    • Evaluation of viral virulence and diabetogenicity in a mouse model.

    Main Results:

    • Distinct coxsackievirus B-4 variants with stable differences in IFN sensitivity were isolated.
    • IFN-sensitive variants demonstrated reduced virulence compared to IFN-insensitive variants.
    • None of the studied coxsackievirus B-4 variants induced diabetes in mice.

    Conclusions:

    • Coxsackievirus variants with varying IFN sensitivity naturally exist.
    • IFN sensitivity is a significant factor modulating coxsackievirus virulence.
    • Further research is needed to understand the role of IFN sensitivity in coxsackievirus-associated diseases.

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