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Related Experiment Video

Updated: May 7, 2026

Optimized Protocol for Retinal Wholemount Preparation for Imaging and Immunohistochemistry
08:32

Optimized Protocol for Retinal Wholemount Preparation for Imaging and Immunohistochemistry

Published on: December 13, 2013

Preferred retinal locus profile during prolonged fixation attempts.

Marco Ulises Morales1, Saker Saker, Rajnikant L Mehta

  • 1Division of Ophthalmology and Visual Sciences; and.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|October 8, 2013
PubMed
Summary

Preferred retinal locus (PRL) points can vary during fixation attempts, especially in patients with unstable fixation. These variations in PRL may be linked to underlying low vision pathologies.

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Area of Science:

  • Ophthalmology
  • Vision Science

Background:

  • The preferred retinal locus (PRL) is the retinal area used for fixation.
  • It is hypothesized that multiple reference points may exist within the PRL during prolonged fixation.

Purpose of the Study:

  • To investigate if distinct reference points exist within the preferred retinal locus (PRL) during prolonged fixation attempts.
  • To clarify the presumption of various representative points within the PRL area.

Main Methods:

  • A prospective, observational case series involving 65 eyes of 41 patients.
  • Macular Integrity Assessment (MAIA) microperimetry was used to calculate initial (PRLi) and final (PRLf) PRL points.
  • Fixation stability was assessed based on PRLi and PRLf calculations.

Main Results:

  • 71% of eyes had stable fixation, with 87% of these showing PRLs over the fovea.
  • 29% of eyes had unstable fixation, with 95% exhibiting different PRLi and PRLf locations.
  • Unstable fixation was associated with conditions like age-related macular degeneration.

Conclusions:

  • Representative points within the PRL can vary during fixation, particularly in unstable fixation.
  • These variations correlate with fixation stability and may be associated with low vision pathologies.