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Updated: May 7, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery of intracranial meningiomas
Bruce E Pollock1, Scott L Stafford, Michael J Link
1Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Abstract:
Stereotactic radiosurgery (SRS) has been performed for intracranial meningiomas for more than 30 years. Small to moderate-sized meningiomas are generally considered good candidates for SRS because of their neuro-imaging and radiobiological characteristics. Patient selection is critical for successful meningioma SRS. Factors related to tumor control and radiation-related complications in patients with WHO grade I or presumed meningiomas include history of prior surgery, tumor volume, and tumor location. Patients with small volume, nonoperated skull-base or tentorial meningiomas typically have the best outcomes after SRS.
Insights
Stereotactic radiosurgery (SRS) is effective for intracranial meningiomas, especially small, non-operated tumors. Careful patient selection based on tumor factors is crucial for successful outcomes and minimizing complications.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Stereotactic radiosurgery (SRS) has a long history, over 30 years, in treating intracranial meningiomas.
- Small to moderate-sized meningiomas are suitable for SRS due to favorable imaging and radiobiological properties.
Purpose of the Study:
- To review patient selection criteria for successful stereotactic radiosurgery (SRS) of intracranial meningiomas.
- To identify factors influencing tumor control and radiation-related complications.
Main Methods:
- Review of clinical data and outcomes for patients with WHO grade I or presumed meningiomas treated with SRS.
- Analysis of factors including prior surgery, tumor volume, and tumor location.
Main Results:
- Patient selection is a critical determinant of successful meningioma SRS.
- Tumor volume, location (skull-base, tentorial), and prior surgical history impact outcomes.
- Small volume, non-operated skull-base or tentorial meningiomas show the best outcomes.
Conclusions:
- Optimal patient selection is paramount for maximizing the efficacy of SRS in treating intracranial meningiomas.
- Factors such as tumor size, location, and surgical history guide treatment decisions for meningioma SRS.
- SRS offers favorable outcomes for select meningioma patients, particularly those with smaller, non-operated tumors.
