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Updated: May 7, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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Published on: September 20, 2017

Curcumin containing monoolein aqueous dispersions: a preformulative study.

Elisabetta Esposito¹, Laura Ravani, Paolo Mariani

¹Department of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.

Materials Science & Engineering. C, Materials for Biological Applications

|October 8, 2013

Summary

This summary is machine-generated.

Monoolein aqueous dispersions (MAD) effectively deliver curcumin (CR), showing high encapsulation and sustained release. Xanthan gum-based MAD further enhanced CR diffusion control for potential drug delivery applications.

Keywords:

CR Cryo-Transmission Electron Microscopy Cubosomes Curcumin Franz cell MAD Monoolein SCE SdFFF Sedimentation Field Flow Fractionation cryo-TEM curcumin monoolein aqueous dispersions stratum corneum epidermis

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Area of Science:

Materials Science
Pharmaceutical Sciences
Biotechnology

Background:

Curcumin (CR) possesses therapeutic properties but suffers from poor bioavailability.
Developing effective drug delivery systems is crucial for enhancing CR's therapeutic potential.

Purpose of the Study:

To produce and characterize monoolein aqueous dispersions (MAD) as a drug delivery system for curcumin (CR).
To evaluate the encapsulation, stability, release, and percutaneous absorption of CR using MAD.

Main Methods:

Production and characterization of MAD using monoolein and various emulsifiers.
Morphological and dimensional analysis via Cryogenic Transmission Electron Microscopy (cryo-TEM), X-ray, and Photon Correlation Spectroscopy (PCS).
In vitro studies for CR encapsulation, stability, release kinetics, and percutaneous absorption through human skin membranes.

Main Results:

MAD formulations yielded heterogeneous dispersions including vesicles, cubosomes, and sponge phases.
The monoolein/poloxamer/sodium cholate mixture showed the highest CR entrapment efficiency and stability over 6 months.
MAD formulations, particularly those with xanthan gum, demonstrated sustained CR release and controlled percutaneous absorption.

Conclusions:

Monoolein aqueous dispersions are promising systems for curcumin drug delivery.
Formulation composition significantly impacts CR encapsulation, stability, and release profiles.
Xanthan gum-modified MAD offer enhanced control over CR diffusion, suggesting potential for topical or transdermal applications.