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Osteonecrosis of the jaw related to everolimus: a case report

Dong Wook Kim1, Young-Soo Jung, Hyung-Sik Park

  • 1Department of Oral & Maxillofacial Surgery, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Republic of Korea.

The British Journal of Oral & Maxillofacial Surgery
|October 8, 2013
PubMed

Insights

Osteonecrosis of the jaw (ONJ) can cause significant patient morbidity. This case suggests that the drug everolimus, an antiangiogenic agent, may contribute to ONJ, potentially due to additive effects with other medications.

Area of Science:

  • Oncology
  • Pharmacology
  • Oral Surgery

Background:

  • Antiresorptive agents are known to cause osteonecrosis of the jaw (ONJ).
  • Antiangiogenic agents, such as everolimus, are increasingly used for managing malignant metastases.
  • Everolimus inhibits mammalian target of rapamycin (mTOR), affecting cell growth, angiogenesis, and survival.

Observation:

  • A patient developed osteonecrosis of the jaw.

Findings:

  • This case is the first to suggest a potential link between everolimus and ONJ.
  • The osteonecrosis may result from the additive effect of everolimus, possibly in combination with other therapies.

Implications:

  • Clinicians should be aware of the potential risk of ONJ when prescribing everolimus, especially in patients receiving antiresorptive agents.
  • Further research is needed to elucidate the exact mechanism and incidence of everolimus-induced ONJ.
Keywords:
ARONJAnti-angiogenic agentAnti-resorptive agent related osteonecrosis of the jawEverolimus

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