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Incretin actions beyond the pancreas: lessons from knockout mice

Daisuke Yabe1, Yutaka Seino

  • 1Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan; Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan.

Current Opinion in Pharmacology
|October 8, 2013
PubMed
Summary

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key incretin hormones. Their receptors mediate glucose control and offer therapeutic potential for diabetes complications beyond the pancreas.

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