Bioerodible system for sequential release of multiple drugs

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Complex diseases often involve multiple biomolecular pathways, necessitating multi-drug therapies.
• Current drug delivery systems may not effectively manage sequential or multiple drug administration.
• Developing advanced delivery systems is crucial for targeted and effective disease treatment.

Purpose of the Study:

• To develop a multilayered, polymer-based system for sequential delivery of multiple drugs.
• To evaluate the in vitro release characteristics of small molecule drugs and proteins from the developed system.
• To assess the potential of the system for treating complex diseases and tissue engineering.

Main Methods:

• Fabrication of a multilayered system using cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P).
• Morphological evaluation of the developed CAPP system.
• In vitro drug release studies of small molecule drugs and a model protein from single and multilayered devices.
• Mathematical modeling to predict drug release profiles.

Main Results:

• The CAPP system demonstrated controlled release of both small molecule drugs and a model protein.
• Single-layered CAPP films exhibited zero-order kinetics based on surface erosion.
• Multilayered CAPP devices successfully achieved intermittent and sequential release of different drugs.
• Mathematical models accurately predicted the observed drug release profiles.

Conclusions:

• The developed CAP/Pluronic F-127 (CAPP) association polymer-based multilayer devices enable localized, sequential delivery of multiple drugs.
• This system holds promise for treating complex disease conditions requiring multi-drug administration.
• Potential applications extend to tissue engineering requiring delivery of multiple biomolecules.