Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431 699 adults.

Journal of neurochemistry·2023

Same author

Longitudinal associations of cardiovascular health and vascular events with incident dementia.

Stroke and vascular neurology·2023

Same author

Cerebral Small Vessel Disease Is Associated with Motor, Cognitive, and Emotional Dysfunction in Multiple System Atrophy.

Journal of Parkinson's disease·2023

Same author

Inflammation and Brain Structure in Alzheimer's Disease and Other Neurodegenerative Disorders: a Mendelian Randomization Study.

Molecular neurobiology·2023

Same author

Association of biological age with health outcomes and its modifiable factors.

Aging cell·2023

Same author

The causal role of circulating amino acids on neurodegenerative disorders: A two-sample Mendelian randomization study.

Journal of neurochemistry·2023

Search research articles

Related Experiment Video

Updated: May 7, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNAs dysregulation in epilepsy.

Meng-Meng Li¹, Xue-Mei Li², Xue-Ping Zheng³

¹Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.

|October 8, 2013

Summary

MicroRNAs (miRNAs) are small RNAs implicated in epilepsy. Dysregulated miRNAs offer potential therapeutic targets for this neurological disorder, with ongoing research in human and animal models.

Keywords:

Dysregulation Epilepsy MicroRNA Pathophysiology Treatment

More Related Videos

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Related Experiment Videos

Last Updated: May 7, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Epilepsy is a neurological disorder defined by recurrent seizures caused by abnormal brain neuronal activity.
MicroRNAs (miRNAs) are key regulators of gene expression with potential roles in neurological disease pathogenesis.
Emerging evidence highlights miRNAs as a critical regulatory layer in gene expression with implications for epilepsy.

Purpose of the Study:

To review current research on microRNAs in epilepsy.
To explore the role of miRNAs in epilepsy pathophysiology.
To provide a foundation for future research into miRNA-based epilepsy therapeutics.

Main Methods:

Review of existing scientific literature on miRNA research in epilepsy.
Analysis of studies involving human patients and animal models of epilepsy.
Examination of identified miRNA targets and pathways relevant to epilepsy.

Main Results:

Numerous specific miRNAs have been found to be dysregulated in epilepsy.
miRNAs play a significant role in the underlying mechanisms of epilepsy.
Several miRNA targets and pathways have been identified in recent studies.

Conclusions:

MicroRNAs are critically involved in the pathophysiology of epilepsy.
Dysregulated miRNAs represent promising targets for novel epilepsy treatments.
Further research is needed to fully understand and leverage the therapeutic potential of miRNAs in epilepsy.