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Updated: May 7, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Development of small-molecule inhibitors targeting adipose triglyceride lipase
Nicole Mayer1, Martina Schweiger2, Matthias Romauch2
1Institute of Organic Chemistry, Graz University of Technology, 8010 Graz, Austria.
Abstract:
Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.
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