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Updated: May 7, 2026
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Ventricular remodeling in heart failure with preserved ejection fraction.
1Division of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA, ashah11@partners.org.
Current Heart Failure Reports
|October 8, 2013
Summary
Heart failure with preserved ejection fraction (HFpEF) shows diverse cardiac structures, not just concentric hypertrophy. Further research is needed to identify HFpEF sub-phenotypes for better treatment.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Heart Failure Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) is a prevalent condition associated with significant morbidity and mortality.
- Traditionally, HFpEF has been linked to hypertensive heart disease and concentric left ventricular (LV) hypertrophy.
- Growing evidence highlights considerable clinical heterogeneity within the HFpEF syndrome.
Purpose of the Study:
- To investigate the variability in left ventricular (LV) structure among patients with HFpEF.
- To challenge the traditional view of HFpEF solely as concentric hypertrophy.
- To lay the groundwork for identifying distinct pathophysiological HFpEF sub-phenotypes.
Main Methods:
- Review of large-scale imaging studies from epidemiological and clinical trial cohorts.
- Analysis of left ventricular (LV) geometry and remodeling patterns in diverse HFpEF populations.
- Assessment of cardiac structure and function using advanced imaging techniques.
Main Results:
- While concentric LV remodeling is common in HFpEF, it is not universally present.
- A significant proportion of HFpEF patients exhibit normal LV geometry.
- Some patients present with eccentric LV patterns, indicating structural diversity.
Conclusions:
- The structural phenotype of HFpEF is more heterogeneous than previously recognized.
- Current understanding of HFpEF requires revision beyond concentric hypertrophy.
- Detailed cardiac assessments are crucial for defining HFpEF sub-phenotypes and guiding future research and therapy.
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