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Updated: May 7, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Challenges in measuring antibiotic consumption.

Leigh Anne Hylton Gravatt¹, Amy L Pakyz

¹Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, 410 North 12th Street, P.O. Box 980533, Richmond, VA, 23298-0533, USA, lahyltongrav@vcu.edu.

Current Infectious Disease Reports

|October 8, 2013

Summary

This summary is machine-generated.

Measuring antibacterial use is key for tracking trends, understanding resistance, and evaluating stewardship programs. Using defined daily dose and prescribed daily dose methods, especially in pediatrics, improves antimicrobial use assessment.

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Area of Science:

Pharmacology
Infectious Diseases
Health Services Research

Background:

Accurate measurement of antibacterial consumption is crucial for monitoring usage patterns over time.
It aids in assessing the relationship between antibacterial use and the development of antimicrobial resistance.
Consistent measures are vital for effective comparisons between institutions and within them.

Purpose of the Study:

To highlight the importance of measuring antibacterial consumption.
To discuss common methods like defined daily dose (DDD) and days of therapy (DOT).
To emphasize the need for tailored approaches, particularly in pediatric populations.

Main Methods:

Review of common antibacterial consumption metrics, including defined daily dose (DDD) and days of therapy (DOT).
Discussion of the prescribed daily dose (PDD) method for evaluating pediatric antibacterial use.
Highlighting the role of computerized pharmacy data in enhancing data collection and analysis.

Main Results:

No single measure of antibacterial consumption is ideal for all scenarios.
The DDD and PDD methods, stratified by weight and age, are valuable for pediatric antimicrobial use evaluation.
Computerized pharmacy data offers potential for improved data collection and analysis.

Conclusions:

Effective measurement of antibacterial consumption is essential for antimicrobial stewardship and resistance monitoring.
A combination of methods, adapted for specific populations like pediatrics, provides a more comprehensive evaluation.
Leveraging technology, such as computerized pharmacy data, can significantly improve the accuracy and utility of consumption metrics.