Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

mRNA Sequencing to Identify Aberrant Splicing in X-linked Alport Syndrome.

Kidney international reports·2026
Same author

Human Kidney Organoids to Uncover Preterm Birth-Associated Low Nephron Endowment.

Nephron·2026
Same author

Spatial Multiomics Reveal Insights Into ADC Efficacy.

European journal of immunology·2026
Same author

Homeostatic pressure of a proliferating multicellular foam with hydromechanical volume regulation.

Biomechanics and modeling in mechanobiology·2026
Same author

Toward actionable interventions in human aging (12th ARDD meeting, 2025).

Aging·2026
Same author

Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: May 7, 2026

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells
10:23

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Bioengineered kidneys: new sights on a distant horizon.

Christoph Kuppe1, Katja Berger, Bart Smeets

  • 1Department of Nephrology and Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

International Urology and Nephrology
|October 8, 2013
PubMed
Summary

Rising end-stage kidney disease necessitates new treatments. A bioengineered kidney from a decellularized scaffold offers a potential solution to organ shortages and reduces long-term immunosuppression complications.

More Related Videos

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells
10:23

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Area of Science:

  • Regenerative Medicine
  • Transplantation Biology
  • Biomaterials Engineering

Background:

  • Increasing global demand for renal replacement therapy.
  • Limitations of current treatments: dialysis and organ transplantation.
  • Challenges in transplantation: organ scarcity and high morbidity due to immunosuppression.

Purpose of the Study:

  • To review a publication on bioengineered kidney transplantation.
  • To explore a novel solution for end-stage kidney disease.
  • To address organ shortage and reduce immunosuppression-related complications.

Main Methods:

  • Decellularization of an organ scaffold.
  • Bioengineering of a biocompatible kidney.
  • Transplantation of the engineered kidney.

Main Results:

  • Successful transplantation of a bioengineered kidney.
  • Potential to overcome donor organ shortage.
  • Mitigation of long-term immunosuppression morbidity.

Conclusions:

  • Bioengineered kidneys from decellularized scaffolds represent a promising advancement.
  • This approach may alleviate critical organ shortages in transplantation.
  • Offers a potential alternative to reduce long-term patient morbidity.