Related Experiment Video
Updated: May 7, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Meth-oxy-anilinium 2-carb-oxy-4,5-di-chloro-benzoate
1Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia.
Abstract:
In the title salt C7H10NO(+)·C8H3Cl2O4 (-) the benzene rings of the cation and anion are essentially parallel [inter-ring dihedral angle 4.8 (2)°]. In the anion the carb-oxy-lic acid and carboxyl-ate groups make dihedral angles of 19.0 (2) and 79.5 (2)°, respectively, with the benzene ring. Aminium N-H⋯O, carb-oxy-lic acid O-H⋯O and weak aromatic C-H⋯O hydrogen-bonding associations with carboxyl O-atom acceptors together with cation-anion π-π ring inter-actions [minimum ring centroid separation = 3.734 (3) Å] give rise to a sheet structure lying parallel to (001).
More Related Videos
09:46Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Reactions at the Benzylic Position: Oxidation and Reduction
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
Nucleophilic Aromatic Substitution: Elimination–Addition
Reactions at the Benzylic Position: Halogenation
Nomenclature of Aromatic Compounds with Multiple Substituents
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...