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Mast cells and middle ear effusion.

L E Stenfors, N Albiin, G D Bloom

    American Journal of Otolaryngology
    |May 1, 1985
    PubMed
    Summary
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    Mast cells in the middle ear release mediators that contribute to fluid buildup, similar to allergic reactions. This suggests a role for mast cells in producing middle ear effusion.

    Area of Science:

    • Immunology
    • Otolaryngology

    Background:

    • Mast cells are key players in inflammatory and allergic responses.
    • They contain potent mediators like histamine within their granules.
    • Mast cells are found in the middle ear, particularly in the pars flaccida and middle ear mucosa.

    Purpose of the Study:

    • To investigate the role of mast cells in the production of middle ear effusion.

    Main Methods:

    • Administration of compound 48/80 to induce mast cell degranulation.
    • Observation of middle ear effusion accumulation.
    • Analysis of eustachian tube and tympanic isthmus patency.

    Main Results:

    • Mast cell degranulation led to histamine-rich effusion in the middle ear.

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  • Blockage of the eustachian tube or tympanic isthmus also caused effusion.
  • These findings indicate mast cells contribute to middle ear effusion.

    • Conclusions:

    • Mast cells likely participate in middle ear effusion production through their mediators.
    • Understanding mast cell involvement may offer new therapeutic targets for middle ear conditions.