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Related Experiment Video

Updated: May 7, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

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Published on: January 3, 2025

Therapeutic antibodies in stroke.

Chye Yun Yu¹, Gandi Ng, Ping Liao

¹Calcium Signaling Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433 Singapore.

Translational Stroke Research

|October 8, 2013

Summary

Immunotherapy shows promise for stroke treatment by targeting various molecules. However, clinical trials face challenges with side effects, necessitating development of specific antibodies.

Area of Science:

Biomedical research
Neuroscience
Immunology

Background:

Immunotherapy is explored for various diseases, including neurodegenerative disorders.
Recanalization therapy is effective for acute ischemic stroke but has a narrow time window.
Adjuvant therapies like immunotherapy are needed for stroke management.

Purpose of the Study:

To review immunotherapy strategies for stroke management.
To discuss targeted molecules and mechanisms in stroke immunotherapy.
To evaluate the efficacy and challenges of immunotherapy in stroke.

Main Methods:

Review of animal models and clinical trials of immunotherapy in stroke.
Analysis of targeted molecules including myelin-associated proteins, N-methyl-d-aspartic acid receptors, cytokines, and cell adhesion molecules.

Keywords:

Antibody Immunotherapy Stroke

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Last Updated: May 7, 2026

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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Investigation of active vaccination and passive antibody approaches.

Main Results:

Different immunotherapy targets have distinct mechanisms in stroke.
Blocking myelin-associated proteins may enhance neuroplasticity.
Blocking adhesion molecules may suppress immune response for neuroprotection.

Conclusions:

Animal studies show encouraging results for immunotherapy in stroke.
Clinical trials with therapeutic antibodies have shown limited success due to side effects.
Developing specific antibodies with minimal side effects remains a significant challenge.