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Enterovirus 74 infection in children
Matthew Peacey1, Richard J Hall, Jing Wang
1Clinical Virology, The Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Wellington, New Zealand.
Plos One
|October 8, 2013
Summary
Enterovirus 74 (EV74), a rare viral infection in children, was identified in New Zealand. This study presents the first complete genome sequence of EV74 from a patient with acute flaccid paralysis.
Area of Science:
- Virology
- Infectious Diseases
- Genomics
Background:
- Enterovirus 74 (EV74) is a rarely detected viral infection affecting children.
- EV74 was identified in New Zealand in 2010 in a child with acute flaccid paralysis (AFP) via polio surveillance.
- Four cases of EV74 were identified in children within six months, marking the first report of EV74 in New Zealand.
Purpose of the Study:
- To describe the near-complete genome sequence of four EV74 isolates from New Zealand.
- To compare these isolates to existing EV74 sequences.
- To analyze recombination events within the EV74 genome.
Main Methods:
- Whole genome sequencing of EV74 isolates.
- Bioinformatic analysis of sequence identity and recombination.
- Comparison with known EV74 and enterovirus sequences.
Main Results:
- Near-complete genome sequences of four New Zealand EV74 isolates were obtained.
- These isolates showed limited sequence identity in non-structural proteins compared to other known EV74 sequences.
- Multiple recombination events were identified in the P2 and P3 regions, typical for enteroviruses.
Conclusions:
- This study provides the first complete EV74 genome sequence from a patient with acute flaccid paralysis.
- The genetic diversity and recombination patterns of EV74 in New Zealand were characterized.
- Further research is needed to understand the epidemiology and pathogenicity of EV74.
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