Photoredox-mediated C-H functionalization and coupling of tertiary aliphatic amines with 2-chloroazoles
Anuradha Singh1, Amandeep Arora, Jimmie D Weaver
1Department of Chemistry, Oklahoma State University , Stillwater, Oklahoma 74078, United States.
Abstract:
Herein, conditions for C-H functionalization of tertiary aliphatic amines and their subsequent coupling with a number of 2-chloroazole derivatives are reported. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to α-azole carbinamines commonly found in post-translationally modified peptides.
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