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Updated: May 7, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Drug-induced acute liver failure
1Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, 5959 Harry Hines Boulevard, Suite 420, Dallas, TX 75390-8887, USA.
Abstract:
Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.
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