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Mineralizing angiopathy with infantile basal ganglia stroke after minor trauma

Lokesh Lingappa1, Ravi Dandu Varma, Sirisharani Siddaiahgari

  • 1Department of Pediatric Neurology, Rainbow Hospital for Women and Children, Hyderabad, India.

Developmental Medicine and Child Neurology
|October 10, 2013
PubMed

Insights

Infants with basal ganglia stroke and lenticulostriate artery mineralization often experience stroke after minor trauma. While most outcomes are good, trauma increases stroke recurrence risk.

Area of Science:

  • Pediatric Neurology
  • Neurovascular Imaging
  • Pediatric Stroke

Background:

  • Basal ganglia strokes in infants are rare and can have various causes.
  • Mineralization of lenticulostriate arteries is an uncommon finding in pediatric stroke.
  • Understanding the specific characteristics and outcomes of this subgroup is crucial for effective management.

Purpose of the Study:

  • To describe a cohort of infants with basal ganglia stroke linked to lenticulostriate artery mineralization.
  • To analyze the clinical presentation, etiological factors, and outcomes of these infants.
  • To identify potential risk factors for stroke recurrence.

Main Methods:

  • Retrospective analysis of infants with subcortical strokes.
  • Identification and characterization of infants with basal ganglia infarcts and lenticulostriate artery mineralization.
  • Evaluation of clinical course, aetiological factors, and recurrence rates.

Main Results:

  • 22 out of 23 infants with basal ganglia stroke had lenticulostriate artery mineralization.
  • Hemiparesis was the most common presentation (20 infants).
  • Minor trauma preceded stroke in 18 infants; no other predisposing factors were identified. Five infants experienced recurrence; 8/17 had complete recovery, 9/17 had mild residual hemiparesis.

Conclusions:

  • Infantile basal ganglia stroke with lenticulostriate artery mineralization is a distinct clinicoradiological entity.
  • Standard investigations for prothrombotic states and vasculopathies were unremarkable.
  • Minor trauma is a significant risk factor for stroke recurrence in this population.
Abstract

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