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Hematologic reference intervals in Cynomolgus (Macaca fascicularis) monkeys.

N Bourgès-Abella1, A Geffré, E Moureaux

  • 1Université de Toulouse, INP, ENVT, Toulouse, France.

Journal of Medical Primatology
|October 10, 2013
PubMed
Summary

Hematology reference intervals for Cynomolgus monkeys (Macaca fascicularis) were established using international guidelines. These intervals aid in interpreting clinical pathology data for this widely used non-human primate model.

Keywords:
a posteriori determinationbloodnon-human primatesreference values

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Area of Science:

  • Comparative Pathology
  • Primate Hematology
  • Biomedical Research

Background:

  • Cynomolgus monkeys (Macaca fascicularis) are crucial non-human primate models in biomedical research.
  • Accurate interpretation of clinical pathology data relies on established reference intervals.
  • Existing reference intervals may not fully represent diverse Cynomolgus populations.

Purpose of the Study:

  • To establish robust hematologic reference intervals for Cynomolgus monkeys.
  • To adhere to guidelines set by the International Federation of Clinical Chemistry and Clinical and Laboratory Standards Institute.
  • To provide a reliable data set for primatology research centers.

Main Methods:

  • Analysis of blood specimens from 272 healthy Cynomolgus monkeys.
  • Utilized a nonparametric method for reference interval establishment.
  • Investigated the influence of age, sex, body weight, and geographic origin on hematologic parameters.

Main Results:

  • Age-related trends observed: slight decreases in hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, with a slight increase in mean corpuscular volume.
  • Geographic origin impacts: monkeys from the Philippines exhibited lower red blood cell concentration, hemoglobin, and hematocrit.
  • Established reference intervals provide a benchmark for hematologic parameters in this species.

Conclusions:

  • The established hematology reference intervals align with international recommendations.
  • These intervals are applicable to research settings utilizing similar Cynomolgus monkey populations and hematology analyzers.
  • This study contributes to standardized data interpretation in non-human primate research.