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Cholesterol: fa(s)t-food for enterovirus genome replication.

Jeroen R P Strating1, Hilde M van der Schaar, Frank J M van Kuppeveld

  • 1Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.

Trends in Microbiology
|October 10, 2013
PubMed
Summary

Enteroviruses hijack host cell membranes to replicate, using clathrin-mediated endocytosis to move cholesterol to replication sites. This cholesterol is essential for efficient viral replication and propagation.

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