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Excess body weight during pregnancy and offspring obesity: potential mechanisms

Oleg Paliy1, Chandrika J Piyathilake2, Anita Kozyrskyj3

  • 1Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|October 10, 2013
PubMed

Insights

Maternal obesity increases offspring obesity risk through various factors like diet and gut microbiota, potentially creating an intergenerational cycle. Understanding these links is crucial for public health interventions.

Area of Science:

  • Public Health
  • Pediatrics
  • Endocrinology

Background:

  • Child and adult obesity rates have risen globally.
  • Obesity is linked to physical health issues (diabetes, cardiovascular disease) and mental health concerns (depression).
  • Infant weight and early weight gain predict later-life obesity.

Purpose of the Study:

  • To review mechanisms linking maternal obesity to offspring obesity.
  • To explore the intergenerational cycle of obesity.

Main Methods:

  • Literature review of current scientific knowledge.
  • Analysis of factors influenced by maternal weight during and after pregnancy.

Main Results:

  • Maternal obesity influences offspring risk via diet, delivery mode, feeding practices, and breast milk.
  • Maternal weight impacts infant gut microbiota composition.
  • These factors contribute to an intergenerational obesity cycle.

Conclusions:

  • Maternal factors significantly influence offspring obesity risk.
  • Interventions targeting maternal weight may disrupt the intergenerational obesity cycle.
  • Further research into these mechanisms is warranted.

Keywords:
ChildDietary patternsInfantMicrobiotaObesityOverweightPregnancy

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