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Updated: May 7, 2026

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
Published on: April 12, 2021
Using human induced pluripotent stem cells to treat retinal disease
S Borooah1, M J Phillips, B Bilican
1MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Ophthalmology, School of Clinical Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
None:
The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.
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