Related Experiment Video
Updated: May 7, 2026
09:10
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
1.0K
DNA methylome: Unveiling your biological age
Ming Li1, Wensu Liu, Tingting Yuan
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Protein & Cell
|October 10, 2013
Summary
Researchers developed a highly accurate model using DNA methylation epigenetic biomarkers to predict aging rate. This breakthrough offers new avenues for studying aging mechanisms and epigenetic factors.
Area of Science:
- Epigenetics and aging research.
- Genomics and bioinformatics.
Background:
- Aging rate is a complex biological process.
- Epigenetic modifications, such as DNA methylation, are known to change with age.
- Predicting biological age accurately remains a challenge.
Purpose of the Study:
- To investigate the relationship between the DNA methylome and the rate of aging.
- To develop a quantitative and reproducible model for predicting aging rate using epigenetic biomarkers.
Main Methods:
- DNA methylation sequencing was performed.
- A predictive model was constructed based on identified epigenetic biomarkers.
Main Results:
- A quantitative and reproducible model accurately predicted aging rate.
- The model demonstrated high predictive accuracy.
Conclusions:
- Epigenetic biomarkers, specifically DNA methylation patterns, can reliably predict aging rate.
- This approach opens possibilities for studying aging mechanisms in stem cells and exploring other epigenetic factors like non-coding RNA and 3D chromatin structure.
Related Concept Videos
03:00Next-generation Sequencing
88.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.0K
01:37Mitochondria
13.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.5K
01:29Replication in Eukaryotes
15.5K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
15.5K
02:31Replication in Eukaryotes
157.1K
Overview
157.1K
01:57Sanger Sequencing
801.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
801.2K
02:41Telomeres and Telomerase
6.4K
6.4K