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Pathogen inactivation: coming of age
1Department of Hemotherapy and Hemostasis, Biomedical Diagnostic Center, University Clinic Hospital, Agustí Pi i Sunyé Biomedical Research Institute, Barcelona, Spain.
Current Opinion in Hematology
|October 10, 2013
Summary
Pathogen inactivation technologies for plasma and platelets are increasingly used globally. Decades of clinical experience confirm the safety and efficacy of these pathogen-inactivated blood components.
Area of Science:
- Blood Transfusion Medicine
- Infectious Disease Control
- Biotechnology
Background:
- Over the past two decades, pathogen inactivation technologies have emerged for blood components.
- These technologies aim to reduce transfusion-transmitted infections.
Purpose of the Study:
- To review available data on pathogen inactivation technologies.
- To summarize the clinical application of inactivated blood products.
Main Methods:
- Literature review of pathogen inactivation technologies.
- Analysis of clinical use data for inactivated plasma and platelets.
Main Results:
- Pathogen inactivation technologies for plasma and platelets are available and widely adopted.
- Extensive clinical experience supports the safety and efficacy of treated blood components.
Conclusions:
- Increased use of pathogen inactivation technologies for plasma and platelets is evident.
- Routine use and clinical trials confirm efficacy and safety criteria are met.
- Implementation varies due to epidemiology, risk perception, and economic factors.
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