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Pharmaceutical analysis by solid-substrate electrospray ionization mass spectrometry with wooden tips.

Yunyun Yang1, Jiewei Deng, Zhong-Ping Yao

  • 1Guangdong Provincial Public Laboratory of Analysis and Testing Technology, China National Analytical Center Guangzhou, Guangzhou, 510070, China, yy_yang@vip.126.com.

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Summary

Wooden tips enable direct electrospray ionization mass spectrometry (ESI-MS) for pharmaceutical analysis. This method efficiently analyzes drug components, detects degradation products, and aids in quality control and origin tracing of herbal products.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Pharmaceutical Analysis

Background:

  • Direct ionization techniques simplify sample preparation for mass spectrometry.
  • Electrospray ionization (ESI) is a versatile ionization method.
  • Novel substrates for ESI can enhance analytical capabilities.

Purpose of the Study:

  • To evaluate wooden tips as a substrate for direct electrospray ionization mass spectrometry (ESI-MS) in pharmaceutical analysis.
  • To assess the applicability of wooden-tip ESI-MS for analyzing diverse pharmaceutical formulations and detecting degradation products.
  • To explore the use of wooden-tip ESI-MS for chemical fingerprinting of herbal products for quality assessment and origin tracing.

Main Methods:

  • Utilized wooden tips as solid substrates for electrospray ionization.
  • Applied wooden-tip ESI-MS to various pharmaceutical dosage forms (tablets, capsules, liquids, etc.).
  • Analyzed active pharmaceutical ingredients, trace degradation products, and complex herbal matrices.

Main Results:

  • Successfully achieved direct ionization and mass spectrometric analysis of active pharmaceutical components across multiple dosage forms.
  • Demonstrated sensitive detection of trace degradation products in pharmaceutical samples.
  • Generated chemical fingerprints for herbal products, providing valuable data for quality assessment and origin tracing.

Conclusions:

  • Wooden-tip ESI-MS is a highly effective and sensitive tool for rapid pharmaceutical analysis.
  • The method exhibits wide applicability for analyzing diverse pharmaceutical products and complex natural products.
  • Wooden-tip ESI-MS shows significant promise for pharmaceutical quality control, authentication, and origin tracing.