Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro
Jie Zhao1, Jinbo Fei, Cuiling Du
1Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China. jbli@iccas.ac.cn.
Chemical Communications (Cambridge, England)
|October 10, 2013
Abstract:
An oxygen generation core-shell structure uploading rose bengal has been fabricated by covalent assembly of catalase and alginate dialdehyde via Schiff's base. The composite can catalyze the decomposition of intracellular H2O2 to increase the concentration of O2, which effectively enhances the anticancer efficiency of photodynamic therapy in vitro.
