25th anniversary article: interfacing nanoparticles and biology: new strategies for biomedicine
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Updated: May 7, 2026
Author Spotlight: Advancing Bioimaging and Therapy with Functional Nanomaterials
Published on: September 13, 2024
Gulen Yesilbag Tonga1, Krishnendu Saha, Vincent M Rotello
1Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
Abstract:
The exterior surface of nanoparticles (NPs) dictates the behavior of these systems with the outside world. Understanding the interactions of the NP surface functionality with biosystems enables the design and fabrication of effective platforms for therapeutics, diagnostics, and imaging agents. In this review, we highlight the role of chemistry in the engineering of nanomaterials, focusing on the fundamental role played by surface chemistry in controlling the interaction of NPs with proteins and cells.
