Related Experiment Video
Updated: May 7, 2026

Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
Published on: March 3, 2014
"I Can't Walk!" Acute Thrombosis of Descending Aorta Causing Paraplegia
Matthew L Mitchell1, Elif Yucebey, Mitchell R Weaver
1Henry Ford Hospital, Department of Emergency Medicine, Detroit, Michigan.
Abstract:
A 50-year-old man presented to the emergency department (ED) with acute, bilateral lower extremity weakness and loss of sensation, as well as absent pulses bilaterally. Computed tomography angiography showed complete occlusion of the aorta below the inferior mesenteric artery, extending to the iliac bifurcations. Echocardiographic findings showed severe systolic dysfunction (ejection fraction of 15%) and cryptic cardiogenic shock in spite of stable vital signs. Prior to early operative intervention, an early goal-oriented hemodynamic strategy of shock management resulted in the resolution of motor and sensory deficits.After definitive surgical intervention, the patient was discharged neurologically intact. Acute aortic occlusion is frequently accompanied by myocardial dysfunction, which can be from mild to severe. The most severe form can even occur with normal vital signs or occult cardiogenic shock. Early detection and goal-directed preoperative hemodynamic optimization, along with surgical intervention in the ED, is required to optimize outcomes.
Related Concept Videos
Peripheral Artery Disease I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Secondary Spinal Cord Injury llI: Pathophysiology
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Spinal Cord Injury ll: Pathophysiology
Peripheral Artery Disease V: Postoperative Nursing Management

