Related Experiment Video
Updated: May 7, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
Published on: March 1, 2024
Emergency department crowding and time to antibiotic administration in febrile infants
Jennifer K Light1, Robyn M Hoelle, Jill Boylston Herndon
1University of Florida, College of Medicine, Department of Emergency Medicine Gainesville, Florida.
Insights
Delayed antibiotic administration in febrile newborns is common in general emergency departments (EDs). However, this study found no link between antibiotic timing and ED crowding, suggesting a need for standardized treatment guidelines.
Area of Science:
- Pediatric Emergency Medicine
- Infectious Disease Management
- Healthcare Operations
Background:
- Early antibiotic administration is crucial for febrile newborns to prevent serious bacterial infections.
- Most children in the US receive emergency care in general emergency departments (EDs), not specialized pediatric ones.
- Understanding factors affecting antibiotic timing in these settings is vital.
Purpose of the Study:
- To investigate the relationship between antibiotic administration time and emergency department (ED) crowding in febrile newborns.
- To analyze this association in a general ED that serves both pediatric and adult patients.
Main Methods:
- Retrospective chart review of 159 newborns presenting to a general ED (2005-2011).
- Analysis of the association between time to antibiotic administration and ED occupancy rates.
- Evaluation of occupancy rates at, before, and after infant presentation.
Main Results:
- Delayed and variable antibiotic administration times were observed in febrile newborns.
- No significant association was found between antibiotic administration time and ED occupancy rate.
- Antibiotic timing did not correlate with hospital length of stay or inpatient mortality.
Conclusions:
- Delayed antibiotic treatment for febrile newborns is prevalent in general EDs but not linked to crowding.
- Variability in ED practice patterns for antibiotic administration was noted.
- Developing standardized guidelines for timely antibiotic administration in this population is recommended.
Introduction:
Early antibiotic administration is recommended in newborns presenting with febrile illness to emergency departments (ED) to avert the sequelae of serious bacterial infection. Although ED crowding has been associated with delays in antibiotic administration in a dedicated pediatric ED, the majority of children that receive emergency medical care in the United States present to EDs that treat both adult and pediatric emergencies. The purpose of this study was to examine the relationship between time to antibiotic administration in febrile newborns and crowding in a general ED serving both an adult and pediatric population.
Methods:
We conducted a retrospective chart review of 159 newborns presenting to a general ED between 2005 and 2011 and analyzed the association between time to antibiotic administration and ED occupancy rate at the time of, prior to, and following infant presentation to the ED.
Results:
We observed delayed and variable time to antibiotic administration and found no association between time to antibiotic administration and occupancy rate prior to, at the time of, or following infant presentation (p>0.05). ED time to antibiotic administration was not associated with hospital length of stay, and there was no inpatient mortality.
Conclusion:
Delayed and highly variable time to antibiotic treatment in febrile newborns was common but unrelated to ED crowding in the general ED study site. Guidelines for time to antibiotic administration in this population may reduce variability in ED practice patterns.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Pharmacokinetics in Pediatric Patients: Drug Excretion
Drug Dosing: Infants and Children
Urine Studies II: Urine Culture and Sensitivity Test
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Dosage Interval and Administration Route: Determination Methods

