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Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population
Xiao-Jin Wu1, Yan-Yan Mi, Hui Yang
1Department of Radiation Oncology, The First People's Hospital of Xuzhou, China.
Background:
Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population.
Patients And Methods:
The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results:
There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes.
Conclusion:
The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.
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