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Updated: May 7, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
[Antidepressant treatment associated hyponatremia -- case report]
Zsófia Bognár1, Gabriella Vonyik, Gábor Gazdag
1Egyesített Szent István és Szent László Kórház-Rendelőintézet, Szent László Kórház, IV. Belgyógyászati osztály, Budapest, Hungary. gazdag@lamb.hu.
Abstract:
Hyponatremia is a potential side-effect of antidepressants that was observed most frequently in connection with compounds acting on the serotonin system. Risk of hyponatremia was found to be higher in the elderly. Authors report a case of a 65-year old male patient who was treated with venlafaxine-mirtazapine combination for recurrent depression. Severe hyponatremia, requiring intensive care, emerged in connection with the treatment. The authors emphasize the importance of the regular checking of serum sodium levels during antidepressant treatment, especially in elderly patients.
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Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...

