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Updated: May 7, 2026

Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope

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Published on: September 14, 2018

Nanometrology.

David J S Birch¹, Philip Yip

¹The Photophysics Research Group, Department of Physics, Centre for Molecular Nanometrology, SUPA, University of Strathclyde, Glasgow, Scotland, UK.

Methods in Molecular Biology (Clifton, N.J.)

|October 11, 2013

Summary

This summary is machine-generated.

This study presents a fluorescence metrology method to measure average nanoparticle size (1-10 nm) by analyzing Brownian rotation. The technique uses the Stokes-Einstein equation for accurate nanoparticle sizing.

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Area of Science:

Colloid and Surface Science
Nanotechnology
Analytical Chemistry

Background:

Accurate nanoparticle size determination is crucial for understanding material properties.
Existing methods may have limitations for nanoparticles in the 1-10 nm range.

Purpose of the Study:

To introduce a novel fluorescence metrology protocol for precise average nanoparticle size determination.
To validate the method for nanoparticles in the 1-10 nm size range.

Main Methods:

Utilizing fluorescence anisotropy decay to measure the rotational correlation time of nanoparticles.
Employing Brownian motion principles and the Stokes-Einstein equation for size calculation.
Attaching a fluorescent dye to nanoparticles via electrostatic or covalent linkage.

Main Results:

Demonstrated successful application of the fluorescence metrology technique.
Accurately determined average nanoparticle sizes within the 1-10 nm range.
Showcased the method's versatility with silica nanoparticles as an example.

Conclusions:

The described fluorescence metrology offers a reliable method for nanoparticle sizing.
The protocol is adaptable for various nanoparticle types beyond silica.
This technique provides valuable insights into nanoparticle behavior in colloidal systems.