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Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness and serum

Murat Ziyrek1, Yelda Tayyareci, Selen Yurdakul

  • 1Clinic of Cardiology, Florence Nightingale Hospital, İstanbul-Turkey. saideaytekin@gmail.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|October 11, 2013
PubMed

Insights

Mitral annular calcification (MAC) is linked to increased carotid intima media thickness (CIMT) and lower serum fetuin-A levels. These factors, along with fetuin-A, may serve as diagnostic markers for MAC.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biochemistry

Background:

  • Mitral annular calcification (MAC) is a degenerative process involving the mitral valve annulus, often associated with atherosclerosis.
  • Fetuin A is recognized as an inhibitor of pathological calcification.
  • The interplay between MAC, atherosclerosis markers like carotid intima media thickness (CIMT), and serum fetuin-A levels requires further investigation.

Purpose of the Study:

  • To investigate the relationship between mitral annular calcification (MAC) and serum fetuin-A levels.
  • To assess the association of MAC with carotid intima media thickness (CIMT) and endothelial dysfunction.
  • To determine the potential of serum fetuin-A and CIMT as diagnostic markers for MAC.

Main Methods:

  • An observational cross-sectional study included 40 patients with MAC and 40 without MAC, all diagnosed with coronary artery disease (CAD).
  • Endothelial function was assessed using brachial artery Doppler ultrasound, and CIMT was measured via carotid artery Doppler ultrasound.
  • Serum fetuin-A levels were quantified, and statistical analyses included linear regression and receiver operator curve analysis.

Main Results:

  • Patients with MAC exhibited significantly decreased endothelial-derived vasodilatory response (EDVR) and increased CIMT.
  • A strong positive correlation was observed between EDVR and serum fetuin-A levels.
  • CIMT and serum fetuin-A were identified as independent factors associated with MAC, with areas under the curve of 0.724 and 0.731, respectively.

Conclusions:

  • Mitral annular calcification (MAC) is closely associated with increased CIMT and altered serum fetuin-A levels.
  • Serum fetuin-A and CIMT demonstrate potential as independent diagnostic markers for MAC.
  • MAC may serve as an early determinant of coronary artery disease (CAD).
Abstract

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