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N-Terminal proBNP Levels and Tissue Doppler Echocardiography in Acute Rheumatic Carditis.

Alyaa A Kotby1, Ghada S El-Shahed, Ola A Elmasry

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ISRN Pediatrics
|October 11, 2013
PubMed
Summary

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is elevated in children with acute rheumatic carditis, indicating active inflammation. Levels decreased as carditis resolved, unlike in children with quiescent rheumatic heart disease or healthy controls.

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Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Disease Biomarkers
  • Rheumatic Heart Disease

Background:

  • Rheumatic heart disease (RHD) is a significant cause of pediatric heart failure globally.
  • N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a known biomarker for pediatric heart conditions.
  • Assessing carditis activity in RHD is crucial for management.

Purpose of the Study:

  • To evaluate NT-proBNP levels in children with acute rheumatic carditis.
  • To compare NT-proBNP levels with quiescent RHD and healthy pediatric controls.
  • To determine NT-proBNP's utility as a marker for carditis activity.

Main Methods:

  • Studied 16 children with acute rheumatic carditis, 33 with quiescent RHD, and 30 healthy children.
  • Utilized transthoracic echocardiography for cardiac and valve function assessment.
  • Employed Tissue Doppler echocardiography to measure E/E' ratio and systolic strain.

Main Results:

  • NT-proBNP levels were significantly higher in the acute rheumatic carditis group.
  • NT-proBNP levels decreased upon resolution of carditis.
  • Echocardiographic indices (strain, E/E') were similar across all three groups.

Conclusions:

  • NT-proBNP is significantly elevated during the acute phase of rheumatic carditis in children.
  • NT-proBNP serves as a sensitive marker for active carditis in RHD.
  • Echocardiographic measures of cardiac function did not differ significantly between acute carditis and other groups.