Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

16.9K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
16.9K
Methods of Medium Optimization01:28

Methods of Medium Optimization

74
Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
74

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BINge: Multispecies Ortholog Clustering for Differential Gene Expression Analyses.

Molecular ecology resources·2026
Same author

Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud.

PLoS computational biology·2025
Same author

Leveraging uncertainty quantification to optimize CRISPR guide RNA selection.

Biology methods & protocols·2025
Same author

Intelligent Drone Swarms to Search for Victims in Post-Disaster Areas.

Sensors (Basel, Switzerland)·2023
Same author

Circadian ribosome profiling reveals a role for the <i>Period2</i> upstream open reading frame in sleep.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Predicting Carcass Weight of Grass-Fed Beef Cattle before Slaughter Using Statistical Modelling.

Animals : an open access journal from MDPI·2023
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
See all related articles

Related Experiment Video

Updated: May 7, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.0K

Optimisation algorithms for microarray biclustering.

Dimitri Perrin, Christophe Duhamel

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study explores genetic algorithms and a new heuristic for analyzing gene expression data from microarrays. These methods effectively identify optimal patterns in biological processes.

    More Related Videos

    Competitive Genomic Screens of Barcoded Yeast Libraries
    11:59

    Competitive Genomic Screens of Barcoded Yeast Libraries

    Published on: August 11, 2011

    19.4K
    Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
    16:37

    Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

    Published on: August 5, 2008

    12.5K

    Related Experiment Videos

    Last Updated: May 7, 2026

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
    07:35

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

    Published on: October 11, 2018

    7.0K
    Competitive Genomic Screens of Barcoded Yeast Libraries
    11:59

    Competitive Genomic Screens of Barcoded Yeast Libraries

    Published on: August 11, 2011

    19.4K
    Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
    16:37

    Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

    Published on: August 5, 2008

    12.5K

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Microarray technology provides simultaneous gene expression profiles for thousands of genes.
    • Analyzing this data through clustering and classification reveals patterns and biological insights.
    • Bipartite graphs are commonly used to represent microarray data, with weighted edges indicating expression levels.

    Purpose of the Study:

    • To evaluate several variations of Genetic Algorithms for biclustering microarray data.
    • To introduce and assess a novel heuristic algorithm called "Propagate" for biclustering.

    Main Methods:

    • Utilizing a previously established weighting scheme for bipartite graphs representing gene and sample relationships.
    • Implementing and comparing multiple Genetic Algorithm variations for biclustering.
    • Applying the new "Propagate" heuristic, which recursively evaluates neighboring solutions.

    Main Results:

    • The evaluated Genetic Algorithms and the "Propagate" heuristic were tested on three well-known microarray datasets.
    • Both approaches demonstrated the ability to identify optimal or near-optimal biclustering solutions.
    • The effectiveness is demonstrated within the context of the chosen weighting scheme.

    Conclusions:

    • Genetic Algorithms and the "Propagate" heuristic are effective search strategies for biclustering gene expression data.
    • These computational methods aid in uncovering complex patterns within large-scale biological datasets.
    • The findings contribute to the advancement of bioinformatics tools for gene expression analysis.