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Updated: May 7, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Physical stability of cholesterol derivatives combined with liposomes and their in vitro behavior
Abstract:
The purpose of this study was to investigate the physical stability and drug release of two cholesterol derivatives (4-cholesterocarbonyl-4'-(N,N,N-triethylamine butyloxyl bromide, CTBBA, and 4-cholesterocarbonyl-4'-(N,N'-diethylamino-butyloxy, CDBA), when combined with doxorubicin (DOX)-loaded liposomes in vitro. CTBBA-liposome revealed a positive charge at a pH between 3 and 10, as indicated by the ζ-potential. DOX-encapsulated CTBBA-liposomes possessed better physical stability both in PBS and in fetal bovine serum (FBS) added to PBS.
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