Nucleoli in vaginal cells of hyperestrogenic and hypoestrogenic women

Nucleoli classified according to their functional morphology were investigated in the vaginal cells of 38 hypoestrogenic and 29 hyperestrogenic women to study the effect of estrogen on these cells. While the cells from hyperestrogenic patients were characterized by the presence of a larger number of compact (active) and ring-shaped (less active/resting) nucleoli, vaginal cells from hypoestrogenic women were characterized by the presence of a larger number of micronucleoli (inactive nucleoli).