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Updated: May 7, 2026

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Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
Published on: June 5, 2019
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Pulse rate variability compared with Heart Rate Variability in children with and without sleep disordered breathing
Summary
Pulse rate variability (PRV) accurately estimates heart rate variability (HRV) in children using time-domain analysis. However, PRV is less precise for frequency-domain HRV parameters, especially in children with sleep disordered breathing (SDB).
Area of Science:
- Cardiology
- Biomedical Engineering
- Pediatric Sleep Medicine
Background:
- Heart Rate Variability (HRV) quantifies autonomic activity using electrocardiogram (ECG) R-R intervals.
- Photoplethysmography (PPG) signals offer a non-invasive alternative for heart rate monitoring.
- Assessing Pulse Rate Variability (PRV) as an HRV surrogate in pediatric populations is crucial.
Purpose of the Study:
- To evaluate the accuracy of PRV derived from PPG as an estimate of HRV in children.
- To compare PRV and HRV in children with and without sleep disordered breathing (SDB).
- To assess the reliability of time-domain and frequency-domain HRV/PRV parameters.
Main Methods:
- Simultaneous ECG and PPG recordings were obtained from 72 children using a mobile phone-connected oximeter.
- Polysomnography was used as the gold standard for data acquisition.
- Correlation and Bland-Altman analyses compared HRV and PRV metrics (SDNN, RMSSD, LF/HF ratio).
Main Results:
- High correlation (r > 0.90) and agreement were observed between HRV and PRV for mean intervals, SDNN, and RMSSD.
- Significant divergence was noted for the LF/HF ratio between HRV and PRV.
- Children with SDB exhibited lower SDNN/RMSSD and higher LF/HF ratios compared to controls.
Conclusions:
- PRV is a valid and accurate surrogate for time-domain HRV analysis in children.
- PRV demonstrates limitations in precisely estimating frequency-domain HRV parameters, particularly the LF/HF ratio.
- PRV can be a valuable tool for assessing autonomic function in pediatric research and clinical settings, especially when ECG is unavailable.
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