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Four levels of wavelength-selective uncaging for oligonucleotides
Alexandre Rodrigues-Correia1, Xenia M M Weyel, Alexander Heckel
1Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt , Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
Abstract:
In this study the new nucleobase-caged nucleotides dT(NpHP) and dT(DEACM) are introduced. Together with two other caging groups (NDBF and NPP) this results in four layers of wavelength-selective uncaging for oligonucleotides, sequentially going from 505 to 440 nm, 365 nm, and finally to 313 nm for the photolysis reaction.
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