Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Erythromycin stearate in acute maxillary sinusitis.

O Kalm, C Kamme, B Bergström

    Scandinavian Journal of Infectious Diseases
    |January 1, 1975
    PubMed
    Summary

    Erythromycin stearate effectively treated acute maxillary sinusitis, with higher doses showing better recovery rates but increased side effects. Concentrations in sinus secretions exceeded minimum inhibitory levels for key bacteria.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of a Digital Computer For Studying Velocity Judgements of Radar Targets.

    Ergonomics·2017
    Same author

    An approach for manganese biomonitoring using a manganese carrier switch in serum from transferrin to citrate at slightly elevated manganese concentration.

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2015
    Same author

    Distribution of diplococcus pneumoniae types in acute otitis media in children and influence of the types on the clinical course in penicillin v therapy.

    Scandinavian journal of infectious diseases·2015
    Same author

    Endoscopic surgery in rhinology and ophthalmology.

    Surgical technology international·2011
    Same author

    Renal safety profiles of ibandronate 6 mg infused over 15 and 60 min: a randomized, open-label study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2008
    Same author

    Oral ibandronate is as active as intravenous zoledronic acid for reducing bone turnover markers in women with breast cancer and bone metastases.

    Annals of oncology : official journal of the European Society for Medical Oncology·2007

    Area of Science:

    • Otolaryngology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Acute maxillary sinusitis is a common condition often requiring antibiotic treatment.
    • Erythromycin stearate is a macrolide antibiotic used for bacterial infections.

    Purpose of the Study:

    • To evaluate the efficacy and safety of erythromycin stearate in treating acute maxillary sinusitis.
    • To determine the concentration of erythromycin in sinus secretions at different dosage regimens.

    Main Methods:

    • A randomized trial involving 76 patients with acute maxillary sinusitis treated with oral erythromycin stearate.
    • Dosages administered were 500 mg twice or three times daily for 10 days.
    • Erythromycin concentrations in sinus secretions were measured, and clinical and radiological outcomes were assessed.

    Related Experiment Videos

    Main Results:

    • Higher dosage (500 mg three times daily) resulted in improved recovery rates (94%) compared to lower dosage (81%).
    • Erythromycin concentrations in sinus secretions were significantly higher with the larger dose (1.3 mug/ml vs 0.6 mug/ml).
    • The higher dose led to more frequent side effects (17/41 patients) requiring discontinuation in 8 patients.

    Conclusions:

    • Erythromycin stearate is effective in treating acute maxillary sinusitis, with higher doses demonstrating superior clinical outcomes.
    • Therapeutic concentrations of erythromycin were achieved in sinus secretions, exceeding MIC for common pathogens like Streptococcus pneumoniae and Haemophilus influenzae.
    • The increased incidence of side effects with higher doses necessitates careful consideration of the risk-benefit profile.