Related Experiment Video
Updated: May 7, 2026
Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally
Published on: April 25, 2025
In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complex
1INSERM, U872, LRMA, Equipe 12 du Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie, UMR S 872, Paris, France; Université Paris Descartes, UMR S 872, Paris, France; Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Abstract:
The in vitro activity of cefoxitin and imipenem was compared for 43 strains of the Mycobacterium abscessus complex, mostly isolated from cystic fibrosis patients. The MICs of imipenem were lower than those of cefoxitin, although the number of imipenem-resistant strains was higher according to the CLSI breakpoints. Strain comparisons indicated that the MICs of cefoxitin were significantly higher for Mycobacterium bolletii than for M. abscessus. The MICs of both β-lactams were higher for the rough morphotype than for the smooth morphotype. The clinical impact of the in vitro difference between the activity of imipenem and that of cefoxitin remains to be determined.
