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Non-typhi Salmonella enterica urinary tract infections
G Mellon1, C Delanoe2, A L Roux3
1Service des maladies infectieuses et tropicales, hôpitaux universitaires Paris-Île-de-France-Ouest, 104, boulevard Raymond-Poincaré, 92380 Garches, France; UFR des sciences de la santé Simone-Veil, université de Versailles-Saint-Quentin-en-Yvelines, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-le-Bretonneux, France.
Objective:
Non-typhi Salmonella enterica urinary tract infections (UTIs) are not frequent and rarely reported in the literature. We aimed to characterize clinical presentations and risk factors for the infection.
Patients And Methods:
We performed a retrospective study of non-typhi Salmonella enterica strains isolated from urine cytobacteriological examinations (UCBE) collected between January 1, 1996 and October 30, 2014 and analyzed by the microbiology laboratories of the university hospitals of the western part of Île-de-France and of Paris, France.
Results:
Twenty UCBEs positive for non-typhi Salmonella enterica were analyzed. The sex ratio was 0.53 and the average age of patients was 57 years. Clinical presentations were acute pyelonephritis, acute cystitis, and prostatitis. Eight cases of bacteremia were identified. Diarrhea was observed in half of patients, either before the UTI or simultaneously. No patient required to be transferred to the intensive care unit. Immunodeficiency and/or diabetes were observed in eight patients. Three patients presented with a uropathy. Prescribed antibiotics were third generation cephalosporins and fluoroquinolones. The average treatment duration was 20 days. A spondylitis and a purulent pleurisy were observed and deemed related to the UTI. Patient outcome was always favorable following treatment prescription.
Conclusion:
Non-typhi Salmonella enterica UTIs are rare. They are mainly observed in elderly patients presenting with immunodeficiency or an underlying urological disorder.
Insights
Non-typhi Salmonella enterica urinary tract infections (UTIs) are rare, often affecting elderly individuals with immunodeficiency or urological issues. Prompt antibiotic treatment leads to favorable outcomes in these uncommon cases.
Area of Science:
- Infectious Diseases
- Urology
- Microbiology
Background:
- Non-typhi Salmonella enterica urinary tract infections (UTIs) are infrequently documented.
- Understanding their clinical spectrum and risk factors is crucial for effective management.
Purpose of the Study:
- To characterize the clinical presentations of non-typhi Salmonella enterica UTIs.
- To identify associated risk factors and patient outcomes.
Main Methods:
- Retrospective analysis of 20 cases of non-typhi Salmonella enterica isolated from urine samples.
- Data collected from university hospitals in Île-de-France and Paris between 1996 and 2014.
Main Results:
- The average patient age was 57 years, with presentations including pyelonephritis, cystitis, and prostatitis.
- Eight cases of bacteremia were noted; diarrhea was common. Immunodeficiency, diabetes, or uropathy were present in several patients.
- Complications like spondylitis and purulent pleurisy occurred, but all patients recovered with antibiotic treatment.
Conclusions:
- Non-typhi Salmonella enterica UTIs are rare, primarily affecting elderly patients with compromised immunity or underlying urological conditions.
- These infections, though uncommon, are treatable with antibiotics, leading to positive patient outcomes.
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01:26Urine Studies II: Urine Culture and Sensitivity Test
01:28Acute Pyelonephritis II: Diagnostic Studies and Management