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Updated: May 7, 2026
07:56
A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
1.4K
Effect of defibrillation threshold testing-induced ventricular fibrillation on renal function.
John H Shin1, Chotikorn Khunnawat, Jose Baez-Escudero
1Section of Cardiology, Department of Medicine, University of Chicago, 5758 S. Maryland Ave, Chicago, IL, USA.
Summary
Defibrillation threshold (DFT) testing during implantable cardioverter defibrillator (ICD) implantation does not impact kidney function. This study found no acute adverse renal effects from DFT testing in patients undergoing ICD procedures.
Area of Science:
- Cardiology
- Nephrology
- Medical Device Technology
Background:
- The impact of defibrillation threshold (DFT) testing on renal function is not well understood.
- This study investigates the acute effects of DFT testing, involving induced ventricular fibrillation (VF), on kidney function in patients receiving implantable cardioverter defibrillators (ICDs).
Purpose of the Study:
- To assess the acute effect of DFT testing on renal function in patients undergoing ICD implantation.
- To determine if DFT testing poses a risk to kidney health post-procedure.
Main Methods:
- A prospective cohort study involving 148 patients undergoing ICD implantation.
- Patients were divided into two groups: DFT testing and no DFT testing.
- Renal function was evaluated using serum creatinine and estimated glomerular filtration rate (GFR) before and 24 hours after the procedure.
Main Results:
- 98 patients underwent DFT testing (mean VF duration 10s), while 50 did not.
- No significant differences in serum creatinine or estimated GFR changes were observed between the DFT and no-DFT groups.
- Baseline GFR was lower in the DFT cohort, but acute changes were similar post-procedure.
Conclusions:
- DFT testing at the time of ICD implantation is safe regarding acute renal function.
- The procedure does not lead to adverse effects on kidney function in the short term.
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