Related Experiment Video
Updated: May 7, 2026

13:13
Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
13.6K
Hematological profile in neonatal jaundice.
Journal of Basic and Clinical Physiology and Pharmacology
|October 12, 2013
Summary
Neonatal jaundice diagnosis can be simplified by analyzing hematological profiles. Specific patterns like anemia and high leukocyte counts indicate serious causes beyond physiological jaundice.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatrics
Background:
- Neonatal jaundice is a common concern requiring early detection and management.
- Identifying the specific etiology of neonatal jaundice can be challenging.
- Hematological parameters offer potential diagnostic insights.
Purpose of the Study:
- To analyze hematological profile parameters in jaundiced neonates.
- To determine the influence of these parameters on various jaundice etiologies.
Main Methods:
- Studied 100 jaundiced neonates admitted to MKCG Medical Hospital.
- Grouped neonates based on leukocyte count, reticulocyte count, and hemoglobin levels.
- Performed blood grouping for mother-baby pairs to identify ABO incompatibility.
Main Results:
- Physiological jaundice showed no significant hematological variations.
- Jaundice associated with ABO incompatibility, septicemia, Rh incompatibility, intracranial hemorrhage, and G6PD deficiency presented with anemia, reticulocytosis, and leukocytosis.
Conclusions:
- Hematological profile analysis can aid in the early diagnosis of neonatal jaundice.
- These findings support a simple, accessible investigation method for neonatal jaundice.
Related Concept Videos
Jaundice
48
Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
48
Changes in Skin Color: Clinical Perspectives
3.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.6K
Rh Blood Group
4.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.4K
Overview of Hematopoiesis
9.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
9.9K
Pharmacokinetics in Pediatric Patients: Drug Metabolism
417
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
417
Pharmacokinetics in Pediatric Patients: Drug Distribution
562
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
562

