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Mathematical modelling of digit specification by a sonic hedgehog gradient.

Thomas E Woolley1, Ruth E Baker, Cheryll Tickle

  • 1Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter, Oxford, United Kingdom; Oxford Centre for Collaborative Applied Mathematics, Mathematical Institute, University of Oxford, Oxford, United Kingdom.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|October 12, 2013
PubMed
Summary

A mathematical model explains chick digit development using a sonic hedgehog (Shh) gradient. This model extends to chick legs but not mouse limbs, suggesting additional mechanisms are needed for more complex limb development.

Keywords:
Shhchick wingdiffusiondigitsgradientgrowthlimbmathematical modellingmorphogen

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